Some sedatives can cause psychological and physical dependence when taken regularly over a period of time, even at therapeutic doses.
Dependent users may get withdrawal symptoms ranging from restlessness and insomnia to convulsions and death.
Chronic urticaria (CU) is a persistent, debiliating condition that causes severe impairment on the quality of life (Qo L) of patient by interrupting work productivity.
Current guidelines recommend second-generation (nonsedating) anti-histamines for the treatment for all forms of urticaria.
Sedatives can be misused to produce an overly-calming effect (alcohol being the classic and most common sedating drug).
The secretion of histamine is stimulated by a wide array of foreign pathogens--think reaction causing stimuli that are transmitted by such things as insect bites, plant pollen, pet dander and many others.Though sedating histamines are frequently used as an add-on therapy in severe cases, they have a negative impact on Qo L by compromising sleep and performance.